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November 29 2016

November 26 2016

November 22 2016

November 20 2016

CNN: The picture was originally posted by Atsunori Kishida, the owner of a Japanese ryokan hotel, Suigo, in Tottori, after an earthquake on October 21.
Somewhat anticlimactically, Kishida told CNN he just carefully opened the door, slipped his arm through and moved the bowls until they were stable.
Reposted bysofiasRekrut-KczosnkowaFreXxXxalyouammetafnordfadenbsoupetergruetzeDevalefuNaitliszSanthebluejanekokolokocatdog2sm0k1nggnunishe1Carridwenmfmfmfwhereisthegurumietta-worldpassingbirdaffiatentacleguytutuszupacebulowalifuLarryGreenSkyp856sofakanteadremdicojustbraindumpactionkeksdarthsadicTabslav2pxfarmaceutka8agiennymyownrealityfupduckylem235thrill-killerarachnephobicckisbackBlacksadhaberindygosalvinorumProjet404NajadapatrzpodnogisaxnjosefinePlonkMrCoffematusskoloryzacjalalunaMissDeWordegitanakingtamaaperturerashfaelmidnightloverPsychoTheRapistlolufoCheshire-CatSakerosmihoshimushufrikadelleorangeugartewerhamsterarisoantprooffastjackhurraikarimolotovcupcakenightmvresohryuankinfinkreghatramentovvamarbearAroncocciuellaloveheartcoreCanadiengetstonedczinokFeichtiSteelbladeMunklokrund2015slovaMalikorsucznikluke1Okruszeknothingiseverythingniklashsetsukaa13thorbenrepostedfromreloveutionzurawianiaczkabrianstormshadowsStageelentarieachaja

November 19 2016

https://www.youtube.com/channel/UCXl3hzTOeEUF18rHgtUV3zA/videos

[hm. can i say i've googled it when google wasn't involved at all?]

November 17 2016

Persepolis

November 14 2016

November 11 2016

Nice piece of artwork; here is it in higher resolution: http://a4size-ska.deviantart.com/art/Eclipse-144235675
Reposted fromathalis athalis

October 31 2016

October 28 2016

Play fullscreen
Crushing different plastics with hydraulic press
Reposted bysofiasmushu

October 27 2016

[cz] Tichá (či Edmundova) soutěska (České Švýcarsko)

[de] Stille Klamm / Edmundsklamm (Böhmische Schweiz)

[en] Edmund's Canyon (Bohemian Switzerland)

[es] Garganta de Edmund (Suiza bohemia)

[geo]

October 25 2016

how is prangent formed (In case of soup embedding screwup: https://www.youtube.com/watch?v=EShUeudtaFg)
Reposted bynordernfbrninjamonkeyMissDeWorde

October 24 2016

October 23 2016

Wow

they really did that. I had to look it up to believe it.

8525 d08f
Reposted frompaket paket

October 22 2016

Psilocybin with psychological support for treatment-resistant depression: an open-label feasibility study

Summary

Background: Psilocybin is a serotonin receptor agonist that occurs naturally in some mushroom species. Recent studies have assessed the therapeutic potential of psilocybin for various conditions, including end-of-life anxiety, obsessive-compulsive disorder, and smoking and alcohol dependence, with promising preliminary results. Here, we aimed to investigate the feasibility, safety, and efficacy of psilocybin in patients with unipolar treatment-resistant depression.

Methods: In this open-label feasibility trial, 12 patients (six men, six women) with moderate-to-severe, unipolar, treatment-resistant major depression received two oral doses of psilocybin (10 mg and 25 mg, 7 days apart) in a supportive setting. There was no control group. Psychological support was provided before, during, and after each session. The primary outcome measure for feasibility was patient-reported intensity of psilocybin’s effects. Patients were monitored for adverse reactions during the dosing sessions and subsequent clinic and remote follow-up. Depressive symptoms were assessed with standard assessments from 1 week to 3 months after treatment, with the 16-item Quick Inventory of Depressive Symptoms (QIDS) serving as the primary efficacy outcome. This trial is registered with ISRCTN, number ISRCTN14426797.

Findings: Psilocybin’s acute psychedelic effects typically became detectable 30–60 min after dosing, peaked 2–3 h after dosing, and subsided to negligible levels at least 6 h after dosing. Mean self-rated intensity (on a 0–1 scale) was 0·51 (SD 0·36) for the low-dose session and 0·75 (SD 0·27) for the high-dose session. Psilocybin was well tolerated by all of the patients, and no serious or unexpected adverse events occurred. The adverse reactions we noted were transient anxiety during drug onset (all patients), transient confusion or thought disorder (nine patients), mild and transient nausea (four patients), and transient headache (four patients). Relative to baseline, depressive symptoms were markedly reduced 1 week (mean QIDS difference –11·8, 95% CI –9·15 to –14·35, p=0·002, Hedges’ g=3·1) and 3 months (–9·2, 95% CI –5·69 to –12·71, p=0·003, Hedges’ g=2) after high-dose treatment. Marked and sustained improvements in anxiety and anhedonia were also noted.

Interpretation: This study provides preliminary support for the safety and efficacy of psilocybin for treatment-resistant depression and motivates further trials, with more rigorous designs, to better examine the therapeutic potential of this approach.

Reposted bypaketdrugsirukandjisyndromepsychedelicsAMPLIDUDEsofias

October 19 2016

Devil's Bridge at Worm's Head (near Rhossili, Wales, UK)
Reposted fromblubber blubber
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